We invite you to participate in this research study because you are a woman or man between 18 and 70 years old and obese. The purpose of this research study is to look at how your skeletal muscles, liver, and fat tissue react to hormones that normally control your blood glucose (sugar). We will evaluate body composition, insulin sensitivity, and how your cells in your adipose tissue (fat) work to regulate blood sugar.

The main purpose of this study is to investigate how well COMP360 psilocybin therapy works to lessen the severity of symptoms in TRD when administered with psychological support compared to placebo and to determine the durability and long-term safety of COMP360 over approximately one year (55 to 62 weeks). The study will also be investigating the safety of COMP360 psilocybin therapy as well as how tolerable it is.